MAX est un gène codé par le symbole MAX. Communément appelé aussi: Protein Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X; BHLHD4. MAX a une masse de 18.28kDa, une longueur d'acide aminé de 160, et est impliqué dans Pheochromocytoma.
Nous proposons 13 des anticorps contre MAX, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements.
Résumé Entrez
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
Spécificité tissulaire
High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
Implication dans la maladie
Pheochromocytoma: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
Similitudes de séquence
Belongs to the MAX family.
Modification post-traductionnelle
Reversible lysine acetylation might regulate the nuclear-cytoplasmic shuttling of specific Max complexes.
Localisation cellulaire
Nucleus. Cell projection > Dendrite.
