MASP2 est un gène codé par le symbole MASP2. Communément appelé aussi: Mannan-binding lectin serine protease 2; MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2. MASP2 a une masse de 75.7kDa, une longueur d'acide aminé de 686, et est impliqué dans MASP2 deficiency.
Nous proposons 8 des anticorps contre MASP2, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
Résumé Entrez
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Spécificité tissulaire
Plasma.
Implication dans la maladie
MASP2 deficiency: A disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.
Similitudes de séquence
Belongs to the peptidase S1 family.
Modification post-traductionnelle
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Localisation cellulaire
Secreted.
