MAdCAM1 est un gène codé par le symbole MADCAM1. Communément appelé aussi: Mucosal addressin cell adhesion molecule 1; MAdCAM-1. MAdCAM1 a une masse de 40.16kDa et une longueur d'acide aminé de 382.
Nous proposons 10 des anticorps contre MAdCAM1, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Résumé Entrez
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
Spécificité tissulaire
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Modification post-traductionnelle
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Localisation cellulaire
Membrane.
