LYK5 est un gène codé par le symbole STRADA. Communément appelé aussi: STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein; Serologically defined breast cancer antigen NY-BR-96; STRADA; STRAD. LYK5 a une masse de 48.37kDa et une longueur d'acide aminé de 431.
Nous proposons 11 des anticorps contre LYK5, élevé dans Lapin, qui sont appropriés pour le WB et ELISA avec des échantillons dérivés de Humain, Souris et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Résumé Entrez
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
Similitudes de séquence
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Localisation cellulaire
Nucleus. Cytoplasm.
