LASP1 est un gène codé par le symbole LASP1. Communément appelé aussi: LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50; MLN50. LASP1 a une masse de 29.72kDa et une longueur d'acide aminé de 261.
Nous proposons 6 des anticorps contre LASP1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Résumé Entrez
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
Localisation cellulaire
Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton.
Associated with the F-actin rich cortical cytoskeleton.
