KChIP2 est un gène codé par le symbole KCNIP2. Communément appelé aussi: Kv channel-interacting protein 2; A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2; KCNIP2. KChIP2 a une masse de 30.91kDa et une longueur d'acide aminé de 270.
Nous proposons 6 des anticorps contre KChIP2, élevé dans Lapin et Souris, qui sont appropriés pour le WB et IHC avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity).
Résumé Entrez
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.
Spécificité tissulaire
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
Similitudes de séquence
Belongs to the recoverin family.
Modification post-traductionnelle
Palmitoylated. Palmitoylation enhances association with the plasma membrane.
Localisation cellulaire
Cell membrane.
Detected on lipid rafts (By similarity).
