Kallikrein 11 est un gène codé par le symbole KLK11. Communément appelé aussi: Kallikrein-11; hK11; Hippostasin; Serine protease 20; Trypsin-like protease; KLK11; PRSS20; TLSP. Kallikrein 11 a une masse de 31.06kDa et une longueur d'acide aminé de 282.
Nous proposons 6 des anticorps contre Kallikrein 11, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Résumé Entrez
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed.
Spécificité tissulaire
Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).
Similitudes de séquence
Belongs to the peptidase S1 family. Kallikrein subfamily.
Modification post-traductionnelle
About 40% of KLK11 is inactivated by internal cleavage after Arg-188. This proteolytic inactivation may be effected by plasminogen.
Localisation cellulaire
Secreted.
