Junctional Adhesion Molecule 1 est un gène codé par le symbole F11R. Communément appelé aussi: Junctional adhesion molecule A; JAM-A; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; F11R; JAM1; JCAM. Junctional Adhesion Molecule 1 a une masse de 32.58kDa et une longueur d'acide aminé de 299.
Nous proposons 8 des anticorps contre Junctional Adhesion Molecule 1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat, Bovin et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
Résumé Entrez
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Spécificité tissulaire
Expressed in endothelium, epithelium and leukocytes (at protein level).
Similitudes de séquence
Belongs to the immunoglobulin superfamily.
Modification post-traductionnelle
N-glycosylated.
Localisation cellulaire
Cell junction > Tight junction. Cell membrane.
Localized at tight junctions of both epithelial and endothelial cells.