IRF2 est un gène codé par le symbole IRF2. Communément appelé aussi: Interferon regulatory factor 2; IRF-2. IRF2 a une masse de 39.35kDa et une longueur d'acide aminé de 349.
Nous proposons 8 des anticorps contre IRF2, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Résumé Entrez
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Spécificité tissulaire
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Similitudes de séquence
Belongs to the IRF family.
Modification post-traductionnelle
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
Localisation cellulaire
Nucleus.
