IRE1 est un gène codé par le symbole ERN1. Communément appelé aussi: Serine/threonine-protein kinase/endoribonuclease Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p-alphaa; ERN1. IRE1 a une masse de 109.74kDa et une longueur d'acide aminé de 977.
Nous proposons 16 des anticorps contre IRE1, élevé dans Lapin, Chèvre et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).
Spécificité tissulaire
Ubiquitously expressed. High levels observed in pancreatic tissue.
Similitudes de séquence
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Modification post-traductionnelle
Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain.
Localisation cellulaire
Endoplasmic reticulum membrane.
