IRAKM est un gène codé par le symbole IRAK3. Communément appelé aussi: Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M; IRAK3. IRAKM a une masse de 67.77kDa, une longueur d'acide aminé de 596, et est impliqué dans Asthma-related traits 5.
Nous proposons 11 des anticorps contre IRAKM, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Résumé Entrez
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Spécificité tissulaire
Expressed predominantly in peripheral blood lymphocytes.
Implication dans la maladie
Asthma-related traits 5: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Similitudes de séquence
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
