Influenza B Virus est un gène codé par le symbole NP. Communément appelé aussi: Nucleoprotein; Nucleocapsid protein; Protein N; NP. Influenza B Virus a une masse de 61.59kDa et une longueur d'acide aminé de 560.
Nous proposons 6 des anticorps contre Influenza B Virus, élevé dans Souris et Chèvre, qui sont appropriés pour le WB, ELISA et ICC/IF avec des échantillons dérivés de Virus de la Grippe B.
Informations sur les Gènes et les Protéines
Résumé UniProt
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Similitudes de séquence
Belongs to the influenza viruses nucleoprotein family.
Modification post-traductionnelle
Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.
Localisation cellulaire
Virion. Host nucleus.
