Influenza A Virus est un gène codé par le symbole HA. Communément appelé aussi: Hemagglutinin; HA. Influenza A Virus a une masse de 63.35kDa et une longueur d'acide aminé de 565.
Nous proposons 6 des anticorps contre Influenza A Virus, élevé dans Souris et Chèvre, qui sont appropriés pour le WB, IHC et ELISA.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Similitudes de séquence
Belongs to the influenza viruses hemagglutinin family.
Modification post-traductionnelle
Palmitoylated.
Localisation cellulaire
Virion membrane. Host apical cell membrane.
Targeted to the apical plasma membrane in epithelial polarized cells through a signal present in the transmembrane domain. Associated with glycosphingolipid- and cholesterol-enriched detergent-resistant lipid rafts.
