IL5 est un gène codé par le symbole IL5. Communément appelé aussi: Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF. IL5 a une masse de 15.24kDa et une longueur d'acide aminé de 134.
Nous proposons 25 des anticorps contre IL5, élevé dans Lapin, Souris, Rat et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Mouton, Goat, Cochon d'Inde et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Résumé Entrez
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Similitudes de séquence
Belongs to the IL-5 family.
Localisation cellulaire
Secreted.
