IL1 alpha est un gène codé par le symbole IL1A. Communément appelé aussi: Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1. IL1 alpha a une masse de 30.61kDa et une longueur d'acide aminé de 271.
Nous proposons 26 des anticorps contre IL1 alpha, élevé dans Lapin, Souris, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin et Lapin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Résumé Entrez
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Similitudes de séquence
Belongs to the IL-1 family.
Localisation cellulaire
Secreted.
The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
