IL-17a est un gène codé par le symbole IL17A. Communément appelé aussi: Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; IL17A; CTLA8; IL17. IL-17a a une masse de 17.5kDa et une longueur d'acide aminé de 155.
Nous proposons 37 des anticorps contre IL-17a, élevé dans Lapin, Souris, Rat, Poulet et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Mouton, Canin, Goat, Cochon d'Inde, Cheval et Primates.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Résumé Entrez
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Spécificité tissulaire
Restricted to activated memory T-cells.
Similitudes de séquence
Belongs to the IL-17 family.
Modification post-traductionnelle
Found both in glycosylated and nonglycosylated forms.
Localisation cellulaire
Secreted.
