IKZF3 est un gène codé par le symbole IKZF3. Communément appelé aussi: Zinc finger protein Aiolos; Ikaros family zinc finger protein 3; ZNFN1A3. IKZF3 a une masse de 58.02kDa et une longueur d'acide aminé de 509.
Nous proposons 7 des anticorps contre IKZF3, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Résumé Entrez
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Spécificité tissulaire
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Similitudes de séquence
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Modification post-traductionnelle
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Localisation cellulaire
Nucleus. Cytoplasm.
