IGFBP3 est un gène codé par le symbole IGFBP3. Communément appelé aussi: Insulin-like growth factor-binding protein 3; IBP-3; IBP3. IGFBP3 a une masse de 31.67kDa et une longueur d'acide aminé de 291.
Nous proposons 15 des anticorps contre IGFBP3, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Résumé Entrez
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Spécificité tissulaire
Expressed by most tissues. Present in plasma.
Modification post-traductionnelle
Phosphorylated by FAM20C in the extracellular medium.
Localisation cellulaire
Secreted.
