ICAM3 est un gène codé par le symbole ICAM3. Communément appelé aussi: Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R. ICAM3 a une masse de 59.54kDa et une longueur d'acide aminé de 547.
Nous proposons 31 des anticorps contre ICAM3, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Résumé Entrez
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécificité tissulaire
Leukocytes.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. ICAM family.
Modification post-traductionnelle
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
Localisation cellulaire
Membrane.
