ICAM2 est un gène codé par le symbole ICAM2. Communément appelé aussi: Intercellular adhesion molecule 2; ICAM-2. ICAM2 a une masse de 30.65kDa et une longueur d'acide aminé de 275.
Nous proposons 15 des anticorps contre ICAM2, élevé dans Lapin, Souris et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Résumé Entrez
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene.
Similitudes de séquence
Belongs to the immunoglobulin superfamily. ICAM family.
Localisation cellulaire
Membrane. Cell projection > Microvillus.
Co-localizes with RDX, EZR and MSN in microvilli.
