Iba1 est un gène codé par le symbole AIF1. Communément appelé aussi: Allograft inflammatory factor 1; AIF-1; Ionized calcium-binding adapter molecule 1; Protein G1; AIF1; G1. Iba1 a une masse de 16.7kDa et une longueur d'acide aminé de 147.
Nous proposons 22 des anticorps contre Iba1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
Résumé Entrez
This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain.
Spécificité tissulaire
Detected in T-lymphocytes and peripheral blood mononuclear cells.
Modification post-traductionnelle
Phosphorylated on serine residues.
Localisation cellulaire
Cytoplasm > Cytoskeleton. Cell projection > Ruffle membrane. Cell projection > Phagocytic cup.
Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
