HPV16 L1 est un gène codé par le symbole L1. Communément appelé aussi: Major capsid protein L1; L1. HPV16 L1 a une masse de 56.28kDa et une longueur d'acide aminé de 505.
Nous proposons 12 des anticorps contre HPV16 L1, élevé dans Lapin et Souris, qui sont appropriés pour le IHC et ICC/IF.
Informations sur les Gènes et les Protéines
Résumé UniProt
Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
Similitudes de séquence
Belongs to the papillomaviridae L1 protein family.
Modification post-traductionnelle
ISGylated by host HERC5, this results in dominant-negative effect on virus infectivity.
Localisation cellulaire
Virion. Host nucleus.
