Hormone sensitive lipase est un gène codé par le symbole LIPE. Communément appelé aussi: Hormone-sensitive lipase; HSL; LIPE. Hormone sensitive lipase a une masse de 116.6kDa, une longueur d'acide aminé de 1076, et est impliqué dans Lipodystrophy, familial partial, 6.
Nous proposons 12 des anticorps contre Hormone sensitive lipase, élevé dans Lapin, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Résumé Entrez
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
Implication dans la maladie
Lipodystrophy, familial partial, 6: A form of lipodystrophy characterized by abnormal subcutaneous fat distribution. Affected individuals have increased visceral fat, impaired lipolysis, dyslipidemia, hepatic steatosis, systemic insulin resistance, and diabetes. Some patients manifest muscular dystrophy.
Similitudes de séquence
Belongs to the 'GDXG' lipolytic enzyme family.
Modification post-traductionnelle
Phosphorylation by AMPK may block translocation to lipid droplets.
Localisation cellulaire
Cell membrane. Membrane > Caveola. Cytoplasm > Cytosol.
Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation.
