HMG14 est un gène codé par le symbole HMGN1. Communément appelé aussi: Non-histone chromosomal protein HMG-14; High mobility group nucleosome-binding domain-containing protein 1; HMGN1. HMG14 a une masse de 10.66kDa et une longueur d'acide aminé de 100.
Nous proposons 6 des anticorps contre HMG14, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Résumé Entrez
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
Similitudes de séquence
Belongs to the HMGN family.
Modification post-traductionnelle
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Localisation cellulaire
Nucleus. Cytoplasm.
Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
