Anticorps HLA-DR

19 produits

HLA-DR est un gène codé par le symbole HLA-DRA. Communément appelé aussi: HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRAAA1. HLA-DR a une masse de 28.61kDa et une longueur d'acide aminé de 254.

Nous proposons 19 des anticorps contre HLA-DR, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Singe, Canin, Félin et Primates.

Informations sur les Gènes et les Protéines

Résumé UniProt
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Résumé Entrez
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Similitudes de séquence
Belongs to the MHC class II family.
Modification post-traductionnelle
Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.
Localisation cellulaire
Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network membrane. Endosome membrane. Lysosome membrane. Late endosome membrane.

The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Liens de base de données
Flow Cytometry - Anti-HLA DR Antibody [L243] (A86735) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
Western Blot - Anti-HLA-DR Antibody (A80638) - Antibodies.com
(5)
SDS-PAGE - Anti-HLA-DR Antibody [IMMU-114] - Low endotoxin, Azide free (A324062) - Antibodies.com
(2)
Voir le roduitAnticorps Recombinant
Immunohistochemistry - Anti-HLA DRA Antibody [19-26.1] (A248849) - Antibodies.com
(3)
SDS-PAGE - Anti-HLA DRA Antibody [169-1B5.2] (A248848) - Antibodies.com
(2)
Western Blot - Anti-HLA-DR Antibody (A13520) - Antibodies.com
Flow Cytometry - Anti-HLA DR Antibody [MEM-12] (FITC) (A85716) - Antibodies.com
(3)
Immunohistochemistry - Anti-HLA DRA Antibody [19-26.1] - BSA and Azide free (A252029) - Antibodies.com
(3)
SDS-PAGE - Anti-HLA DRA Antibody [169-1B5.2] - BSA and Azide free (A252028) - Antibodies.com
(2)
Western Blot - Anti-HLA-DR Antibody (A80639) - Antibodies.com
Flow Cytometry - Anti-HLA DR Antibody [L243] (FITC) (A86732) - Antibodies.com
Western Blot - Anti-HLA-DR Antibody [ARC0518] (A8814) - Antibodies.com
(2)
SDS-PAGE - Anti-HLA DRA Antibody [IPO-10] - BSA and Azide free (A252026) - Antibodies.com
Western Blot - Anti-HLA DR Antibody [MEM-267] (A85931) - Antibodies.com
Voir le roduitTaille d'Essai de 10µg
SDS-PAGE - Anti-HLA DRA Antibody [IPO-10] (A248846) - Antibodies.com
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Voir le roduitTaille d'Essai de 10µg
Western blot - HLA-DRA Antibody from Signalway Antibody (32324) - Antibodies.com
(4)
Anti-HLA-DRA Antibody from Bioworld Technology (BS6622) - Antibodies.com
(2)
HLA-DR antibody from Signalway Antibody (23013) - Antibodies.com

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