Histone H2A.Z est un gène codé par le symbole H2AZ1. Communément appelé aussi: H2A/z; H2AZ1; H2AFZ; H2AZ. Histone H2A.Z a une masse de 13.55kDa et une longueur d'acide aminé de 128.
Nous proposons 12 des anticorps contre Histone H2A.Z, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, IP et ChIP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Résumé Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
Similitudes de séquence
Belongs to the histone H2A family.
Modification post-traductionnelle
Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Localisation cellulaire
Nucleus. Chromosome.