Histone H2A est un gène codé par le symbole H2AC4. Communément appelé aussi: Histone H2A type 1-B/E.2/a/m; H2AC4; H2AFM; HIST1H2AB. Histone H2A a une masse de 14.14kDa et une longueur d'acide aminé de 130.
Nous proposons 16 des anticorps contre Histone H2A, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Résumé Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Similitudes de séquence
Belongs to the histone H2A family.
Modification post-traductionnelle
Deiminated on Arg-4 in granulocytes upon calcium entry.
Localisation cellulaire
Nucleus. Chromosome.
