Histone H1 est un gène codé par le symbole H1-0. Communément appelé aussi: Histone H1.0'(0); H1-0; H1F0; H1FV. Histone H1 a une masse de 20.86kDa et une longueur d'acide aminé de 194.
Nous proposons 32 des anticorps contre Histone H1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Résumé Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes.
Similitudes de séquence
Belongs to the histone H1/H5 family.
Modification post-traductionnelle
Phosphorylated on Ser-17 in RNA edited version.
Localisation cellulaire
Nucleus. Chromosome.
The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
