Hepatitis B Virus Surface Antigen est un gène codé par le symbole S. Communément appelé aussi: Large envelope protein; L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S. Hepatitis B Virus Surface Antigen a une masse de 42.35kDa et une longueur d'acide aminé de 389.
Nous proposons 9 des anticorps contre Hepatitis B Virus Surface Antigen, élevé dans Lapin, Souris et Human, qui sont appropriés pour le IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain.
Informations sur les Gènes et les Protéines
Résumé UniProt
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
Similitudes de séquence
Belongs to the orthohepadnavirus major surface antigen family.
Modification post-traductionnelle
Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region.
Localisation cellulaire
Virion membrane.
Utilisation biotechnologique
Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response.
