Heparin Cofactor II est un gène codé par le symbole SERPIND1. Communément appelé aussi: Heparin cofactor 2; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1; SERPIND1; HCF2. Heparin Cofactor II a une masse de 57.07kDa, une longueur d'acide aminé de 499, et est impliqué dans Thrombophilia due to heparin cofactor 2 deficiency.
Nous proposons 6 des anticorps contre Heparin Cofactor II, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Résumé Entrez
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.
Spécificité tissulaire
Expressed predominantly in liver. Also present in plasma.
Implication dans la maladie
Thrombophilia due to heparin cofactor 2 deficiency: A hemostatic disorder characterized by a tendency to recurrent thrombosis.
Similitudes de séquence
Belongs to the serpin family.
Modification post-traductionnelle
Phosphorylated by FAM20C in the extracellular medium.
