Heme Oxygenase 1 est un gène codé par le symbole HMOX1. Communément appelé aussi: HO-1; HMOX1; HO; HO1. Heme Oxygenase 1 a une masse de 32.82kDa, une longueur d'acide aminé de 288, et est impliqué dans Heme oxygenase 1 deficiency.
Nous proposons 16 des anticorps contre Heme Oxygenase 1, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Singe, Canin, Cochon d'Inde et Hamster.
Informations sur les Gènes et les Protéines
Résumé UniProt
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Résumé Entrez
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
Spécificité tissulaire
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Implication dans la maladie
Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Similitudes de séquence
Belongs to the heme oxygenase family.
Localisation cellulaire
Microsome. Endoplasmic reticulum membrane.
