HEC1 est un gène codé par le symbole NDC80. Communément appelé aussi: Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein HsKinetochore-associated protein 2; Retinoblastoma-associated protein HEC; NDC80; HEC; KNTC2. HEC1 a une masse de 73.91kDa et une longueur d'acide aminé de 642.
Nous proposons 6 des anticorps contre HEC1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).
Résumé Entrez
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
Similitudes de séquence
Belongs to the NDC80/HEC1 family.
Modification post-traductionnelle
Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
Localisation cellulaire
Nucleus. Chromosome > Centromere > Kinetochore.
Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.
