GRP94 est un gène codé par le symbole HSP90B1. Communément appelé aussi: Endoplasmin; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; gp96 homolog; HSP90B1; TRA1. GRP94 a une masse de 92.47kDa et une longueur d'acide aminé de 803.
Nous proposons 23 des anticorps contre GRP94, élevé dans Lapin, Souris, Chèvre et Rat, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Lapin, Singe, Mouton, Poulet, Canin, Cochon d'Inde, Hamster, Cheval et Xenopus.
Informations sur les Gènes et les Protéines
Résumé UniProt
Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity).
Résumé Entrez
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.
Similitudes de séquence
Belongs to the heat shock protein 90 family.
Localisation cellulaire
Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
