GRK2 est un gène codé par le symbole GRK2. Communément appelé aussi: Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1. GRK2 a une masse de 79.57kDa et une longueur d'acide aminé de 689.
Nous proposons 19 des anticorps contre GRK2, élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Canin.
Informations sur les Gènes et les Protéines
Résumé UniProt
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Résumé Entrez
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Spécificité tissulaire
Expressed in peripheral blood leukocytes.
Similitudes de séquence
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Localisation cellulaire
Cytoplasm. Cell membrane.
