GRK1 est un gène codé par le symbole GRK1. Communément appelé aussi: Rhodopsin kinase RK; G protein-coupled receptor kinase 1; RHOK. GRK1 a une masse de 63.53kDa, une longueur d'acide aminé de 563, et est impliqué dans Night blindness, congenital stationary, Oguchi type 2.
Nous proposons 11 des anticorps contre GRK1, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity).
Résumé Entrez
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
Spécificité tissulaire
Retinal-specific. Expressed in rods and cones cells.
Implication dans la maladie
Night blindness, congenital stationary, Oguchi type 2: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.
Similitudes de séquence
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Modification post-traductionnelle
Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP.
Localisation cellulaire
Membrane. Cell projection > Cilium > Photoreceptor outer segment.
Subcellular location is not affected by light or dark conditions.
