GRIK1 est un gène codé par le symbole GRIK1. Communément appelé aussi: Glutamate receptor ionotropic, kainate 1; GluK1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GLUR5. GRIK1 a une masse de 103.98kDa et une longueur d'acide aminé de 918.
Nous proposons 10 des anticorps contre GRIK1, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, IHC et ELISA avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Résumé Entrez
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Spécificité tissulaire
Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
Similitudes de séquence
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
Localisation cellulaire
Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane.
