GPCR GPR75 est un gène codé par le symbole GPR75. Communément appelé aussi: Probable G-protein coupled receptor 75; GPR75. GPCR GPR75 a une masse de 59.36kDa et une longueur d'acide aminé de 540.
Nous proposons 14 des anticorps contre GPCR GPR75, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Résumé Entrez
GPR75 is a member of the G protein-coupled receptor family. GPRs are cell surface receptors that activate guanine-nucleotide binding proteins upon the binding of a ligand.
Spécificité tissulaire
Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
