GPCR GPR40 est un gène codé par le symbole FFAR1. Communément appelé aussi: Free fatty acid receptor 1; G-protein coupled receptor 40; FFAR1; GPR40. GPCR GPR40 a une masse de 31.46kDa et une longueur d'acide aminé de 300.
Nous proposons 8 des anticorps contre GPCR GPR40, élevé dans Lapin et Chèvre, qui sont appropriés pour le WB, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris, Rat et Singe.
Informations sur les Gènes et les Protéines
Résumé UniProt
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Résumé Entrez
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
Spécificité tissulaire
Detected in brain and pancreas. Detected in pancreatic beta cells.
Similitudes de séquence
Belongs to the G-protein coupled receptor 1 family.
Localisation cellulaire
Cell membrane.
