GM-CSF Receptor alpha est un gène codé par le symbole CSF2RA. Communément appelé aussi: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF-R-alpha; CDw116; CSF2RA; CSF2R; CSF2RY. GM-CSF Receptor alpha a une masse de 46.21kDa, une longueur d'acide aminé de 400, et est impliqué dans Pulmonary surfactant metabolism dysfunction 4.
Nous proposons 13 des anticorps contre GM-CSF Receptor alpha, élevé dans Lapin, Souris et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF, Cytométrie en Flux et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Résumé Entrez
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Implication dans la maladie
Pulmonary surfactant metabolism dysfunction 4: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Similitudes de séquence
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Localisation cellulaire
Cell membrane.
