Glycoprotein VI est un gène codé par le symbole GP6. Communément appelé aussi: Platelet GPVI; Glycoprotein 6; GP6. Glycoprotein VI a une masse de 36.87kDa, une longueur d'acide aminé de 339, et est impliqué dans Bleeding disorder, platelet-type 11.
Nous proposons 6 des anticorps contre Glycoprotein VI, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Résumé Entrez
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Spécificité tissulaire
Megakaryocytes and platelets.
Implication dans la maladie
Bleeding disorder, platelet-type 11: A mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen.
Modification post-traductionnelle
N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Localisation cellulaire
Cell membrane.
