Glutamate Receptor 1 (AMPA subtype) est un gène codé par le symbole GRIA1. Communément appelé aussi: Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1; GRIA1; GLUH1; GLUR1. Glutamate Receptor 1 (AMPA subtype) a une masse de 101.51kDa et une longueur d'acide aminé de 906.
Nous proposons 29 des anticorps contre Glutamate Receptor 1 (AMPA subtype), élevé dans Lapin, Souris et Chèvre, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Singe, Poulet, Canin et Hamster.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Résumé Entrez
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Spécificité tissulaire
Widely expressed in brain.
Similitudes de séquence
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
Modification post-traductionnelle
Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Localisation cellulaire
Cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane. Cell junction > Synapse > Postsynaptic density membrane. Cell projection > Dendrite. Cell projection > Dendritic spine. Early endosome membrane. Recycling endosome membrane.
Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).
