Glucagon Receptor est un gène codé par le symbole GCGR. Communément appelé aussi: GL-R; GCGR. Glucagon Receptor a une masse de 54.01kDa et une longueur d'acide aminé de 477.
Nous proposons 7 des anticorps contre Glucagon Receptor, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Résumé Entrez
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
Similitudes de séquence
Belongs to the G-protein coupled receptor 2 family.
Modification post-traductionnelle
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.
Localisation cellulaire
Cell membrane.
Is rapidly internalized after ligand-binding.
