GLS2 est un gène codé par le symbole GLS2. Communément appelé aussi: Glutaminase liver isoform, mitochondrial; GLS; L-glutaminase; L-glutamine amidohydrolase; GA. GLS2 a une masse de 66.32kDa et une longueur d'acide aminé de 602.
Nous proposons 2 des anticorps contre GLS2, élevé dans Lapin, qui sont appropriés pour le WB et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Résumé Entrez
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms.
Spécificité tissulaire
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
Similitudes de séquence
Belongs to the glutaminase family.
Localisation cellulaire
Mitochondrion.
