GLP1R est un gène codé par le symbole GLP1R. Communément appelé aussi: Glucagon-like peptide 1 receptor; GLP-1 receptor. GLP1R a une masse de 53.03kDa et une longueur d'acide aminé de 463.
Nous proposons 8 des anticorps contre GLP1R, élevé dans Lapin, Chèvre et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris, Rat et Porcin.
Informations sur les Gènes et les Protéines
Résumé UniProt
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Résumé Entrez
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Similitudes de séquence
Belongs to the G-protein coupled receptor 2 family.
Modification post-traductionnelle
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Localisation cellulaire
Cell membrane.
