GBP1 est un gène codé par le symbole GBP1. Communément appelé aussi: Guanylate-binding protein 1; GTP-binding protein 1; GBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1. GBP1 a une masse de 67.93kDa et une longueur d'acide aminé de 592.
Nous proposons 13 des anticorps contre GBP1, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Résumé Entrez
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
Similitudes de séquence
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Modification post-traductionnelle
Isoprenylation is required for proper subcellular location.
Localisation cellulaire
Cytoplasm. Golgi apparatus membrane. Cell membrane. Secreted.
Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
