Gastric Inhibitory Polypeptide Receptor est un gène codé par le symbole GIPR. Communément appelé aussi: GIP-R; Glucose-dependent insulinotropic polypeptide receptor; GIPR. Gastric Inhibitory Polypeptide Receptor a une masse de 53.16kDa et une longueur d'acide aminé de 466.
Nous proposons 6 des anticorps contre Gastric Inhibitory Polypeptide Receptor, élevé dans Lapin et Human, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et Cytométrie en Flux avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Résumé Entrez
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
Similitudes de séquence
Belongs to the G-protein coupled receptor 2 family.
Modification post-traductionnelle
N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Localisation cellulaire
Cell membrane.
