GAP43 est un gène codé par le symbole GAP43. Communément appelé aussi: Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46. GAP43 a une masse de 24.8kDa et une longueur d'acide aminé de 238.
Nous proposons 19 des anticorps contre GAP43, élevé dans Lapin, Souris et Poulet, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris, Rat, Bovin, Porcin, Singe, Poulet, Canin, Félin, Cheval, Xenopus et Poisson Zèbre.
Informations sur les Gènes et les Protéines
Résumé UniProt
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Résumé Entrez
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Similitudes de séquence
Belongs to the neuromodulin family.
Modification post-traductionnelle
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Localisation cellulaire
Cell membrane. Cell projection > Growth cone membrane. Cell junction > Synapse. Cell projection > Filopodium membrane. Perikaryon. Cell projection > Dendrite. Cell projection > Axon. Cytoplasm.
Cytoplasmic surface of growth cone and synaptic plasma membranes.
