GAK est un gène codé par le symbole GAK. Il est également connu sous le nom de Cyclin-G-associated kinase. GAK a une masse de 143.19kDa et une longueur d'acide aminé de 1311.
Nous proposons 6 des anticorps contre GAK, élevé dans Lapin et Souris, qui sont appropriés pour le WB, IHC, ELISA, ICC/IF et IP avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Résumé Entrez
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.
Spécificité tissulaire
Ubiquitous. Highest in testis.
Similitudes de séquence
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Localisation cellulaire
Cytoplasm > Perinuclear region. Golgi apparatus > trans-Golgi network. Cell junction > Focal adhesion.
Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
