GABARAP est un gène codé par le symbole GABARAP. Communément appelé aussi: Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46; FLC3B. GABARAP a une masse de 13.92kDa et une longueur d'acide aminé de 117.
Nous proposons 10 des anticorps contre GABARAP, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et ICC/IF avec des échantillons dérivés de Humain, Souris et Rat.
Informations sur les Gènes et les Protéines
Résumé UniProt
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15977068). Through its interaction with the reticulophagy receptor TEX264, paticipates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538).
Résumé Entrez
Gamma-aminobutyric acid A receptors
Spécificité tissulaire
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Similitudes de séquence
Belongs to the ATG8 family.
Modification post-traductionnelle
The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.
Localisation cellulaire
Endomembrane system. Cytoplasm > Cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle > Autophagosome. Cytoplasmic vesicle.
Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity).
