Anticorps GABA B Receptor 2

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GABA B Receptor 2 est un gène codé par le symbole GABBR2. Communément appelé aussi: Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; G-protein coupled receptor 51; HG20; GABBR2; GPR51; GPRC3B. GABA B Receptor 2 a une masse de 105.82kDa, une longueur d'acide aminé de 941, et est impliqué dans les maladies: Neurodevelopmental disorder with poor language and loss of hand skills; Epileptic encephalopathy, early infantile, 59.

Nous proposons 7 des anticorps contre GABA B Receptor 2, élevé dans Lapin, qui sont appropriés pour le WB, IHC, ELISA et IP avec des échantillons dérivés de Humain, Souris, Rat et Félin.

Informations sur les Gènes et les Protéines

Résumé UniProt
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
Résumé Entrez
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Spécificité tissulaire
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622).
Implication dans la maladie
Neurodevelopmental disorder with poor language and loss of hand skills: An autosomal dominant disorder characterized by psychomotor developmental stagnation or regression. NDPLHS manifest in the first years of life as loss of purposeful hand movements, loss of language, and intellectual disability.

Epileptic encephalopathy, early infantile, 59: A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE59 is an autosomal dominant condition characterized by onset of refractory seizures in early infancy.
Similitudes de séquence
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Localisation cellulaire
Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane.

Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.
Anti-GABA B Receptor 2 Antibody from FabGennix (GABAB2-201AP) - Antibodies.com
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Anti-GABA B Receptor 2 Antibody from FabGennix (GABAB2-212AP) - Antibodies.com
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GABA B Receptor 2 Positive Control from FabGennix (PC-GABAB2) - Antibodies.com

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